Title : The isoforms of α-actin and myosin affect the Ca2+ regulation of the actin-myosin interaction in the heart.

Pub. Date : 2017 Aug 19

PMID : 28623140






3 Functional Relationships(s)
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1 We believe that the difference in the amino acid sequence of alpha-actin can affect the calcium regulation of the actin-myosin interaction. Calcium myosin heavy chain 14 Homo sapiens
2 To test this hypothesis, we investigated effects of the isoforms of alpha-actin, cardiac and skeletal, and the isoforms of cardiac myosin on the calcium regulation of the actin-myosin interaction in an in vitro motility assay using reconstructed regulated thin filaments. Calcium myosin heavy chain 14 Homo sapiens
3 The results show that isoforms of alpha-actin and the ratio of alpha/beta-chains of Tpm differently affect the calcium regulation of the actin-myosin interaction in myocardium in dependence on cardiac myosin isoforms. Calcium myosin heavy chain 14 Homo sapiens