Pub. Date : 2017 Jun
PMID : 28622037
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of the AKT/mTOR Pathway Augments the Anticancer Effects of Sorafenib in Thyroid Cancer. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | RESULTS: The results indicate that sorafenib simultaneously inhibited the activities of the MAPK and PI3K/AKT/mTOR pathways in thyroid cancer cells. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Sorafenib in combination with PI3K/AKT/mTOR inhibition by NVP-BEZ235 or AKT siRNA enhanced apoptosis and proliferation suppression. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | CONCLUSIONS: The evidence of this study suggests that a combinatorial approach that inhibits both the MAPK and PI3K/AKT/mTOR pathways exerts a greater antitumor effect than sorafenib alone in thyroid cancer cell lines. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |