Title : Targeted activation of the SHP-1/PP2A signaling axis elicits apoptosis of chronic lymphocytic leukemia cells.

Pub. Date : 2017 Aug

PMID : 28619847






1 Functional Relationships(s)
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1 One of the effects of Lyn"s action is spatial and functional segregation of the tyrosine phosphatase SHP-1 into two pools, one beneath the plasma membrane in an active state promoting pro-survival signals, the other in the cytosol in an inhibited conformation and unable to counter the elevated level of cytosolic tyrosine phosphorylation. Tyrosine protein tyrosine phosphatase non-receptor type 6 Homo sapiens