Title : Loops D, E and G in the Drosophila Dα1 subunit contribute to high neonicotinoid sensitivity of Dα1-chicken β2 nicotinic acetylcholine receptor.

Pub. Date : 2018 Jun

PMID : 28616862






4 Functional Relationships(s)
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1 EXPERIMENTAL APPROACH: Computer models of the (Dalpha1)3 (beta2)2 nACh receptor in complex with imidacloprid and thiacloprid were generated. thiacloprid nicotinic Acetylcholine Receptor alpha1 Drosophila melanogaster
2 However, the R57S mutation in loop G, although having minimal effect on imidacloprid"s actions, reduced the affinity of thiacloprid for the (Dalpha1)3 (beta2)2 nACh receptor, while scarcely affecting thiacloprid"s action on the (Dalpha1)2 (beta2)3 nACh receptor. thiacloprid nicotinic Acetylcholine Receptor alpha1 Drosophila melanogaster
3 However, the R57S mutation in loop G, although having minimal effect on imidacloprid"s actions, reduced the affinity of thiacloprid for the (Dalpha1)3 (beta2)2 nACh receptor, while scarcely affecting thiacloprid"s action on the (Dalpha1)2 (beta2)3 nACh receptor. thiacloprid nicotinic Acetylcholine Receptor alpha1 Drosophila melanogaster
4 Combining the E78K mutation with the R57S;K140T mutations resulted in a selective reduction of thiacloprid"s affinity for the (Dalpha1)3 (beta2)2 nACh receptor. thiacloprid nicotinic Acetylcholine Receptor alpha1 Drosophila melanogaster