Title : miR-101 alleviates chemoresistance of gastric cancer cells by targeting ANXA2.

Pub. Date : 2017 Aug

PMID : 28609840






8 Functional Relationships(s)
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1 miR-101 alleviates chemoresistance of gastric cancer cells by targeting ANXA2. mir-101 annexin A2 Homo sapiens
2 Luciferase reporter assay, RNA immunoprecipitation (RIP) and qRT-PCR were applied to confirm whether miR-101 could target ANXA2 and regulate its expression. mir-101 annexin A2 Homo sapiens
3 A negative correlation between miR-101 and ANXA2 expression was observed in GC tissues. mir-101 annexin A2 Homo sapiens
4 ANXA2 was identified as a direct target of miR-101 and miR-101 negatively regulated ANXA2 expression. mir-101 annexin A2 Homo sapiens
5 ANXA2 was identified as a direct target of miR-101 and miR-101 negatively regulated ANXA2 expression. mir-101 annexin A2 Homo sapiens
6 ANXA2 was identified as a direct target of miR-101 and miR-101 negatively regulated ANXA2 expression. mir-101 annexin A2 Homo sapiens
7 Moreover, ectopic expression of ANXA2 reversed the effect of miR-101 on P-gp expression, cell viability and apoptosis. mir-101 annexin A2 Homo sapiens
8 CONCLUSION: miR-101 alleviated chemoresistance of gastric cancer cells by targeting ANXA2. mir-101 annexin A2 Homo sapiens