Title : Dendritic overgrowth and elevated ERK signaling during neonatal development in a mouse model of autism.

Pub. Date : 2017

PMID : 28609458






3 Functional Relationships(s)
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1 Biochemical analysis further showed that the extracellular signal-regulated kinases (ERK) pathway was up-regulated in the hippocampus of neonatal BTBR animals. btbr mitogen-activated protein kinase 1 Mus musculus
2 Biochemical analysis further showed that the extracellular signal-regulated kinases (ERK) pathway was up-regulated in the hippocampus of neonatal BTBR animals. btbr mitogen-activated protein kinase 1 Mus musculus
3 Since dendritic structure is critical for information integration and relay, our data suggest that altered development of dendrites could potentially contribute to impaired hippocampal function and behavior observed in the BTBR model, and that this might be related to increased activation of the ERK pathway. btbr mitogen-activated protein kinase 1 Mus musculus