Title : Two-step ATP-driven opening of cohesin head.

Pub. Date : 2017 Jun 12

PMID : 28607419






3 Functional Relationships(s)
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1 The study allows the thorough analysis of the opening events at the atomic scale: i) ATP hydrolysis at the Smc1A site, evaluating the role of the carboxy-terminal domain of Rad21 in the process; ii) the activation of the Smc3 site potentially mediated by the movement of specific amino acids; and iii) opening of the head domains after the two ATP hydrolysis events. Adenosine Triphosphate structural maintenance of chromosomes 3 Homo sapiens
2 Our study suggests that the cohesin ring opening is triggered by a sequential activation of the ATP sites in which ATP hydrolysis at the Smc1A site induces ATPase activity at the Smc3 site. Adenosine Triphosphate structural maintenance of chromosomes 3 Homo sapiens
3 Our study suggests that the cohesin ring opening is triggered by a sequential activation of the ATP sites in which ATP hydrolysis at the Smc1A site induces ATPase activity at the Smc3 site. Adenosine Triphosphate structural maintenance of chromosomes 3 Homo sapiens