Title : The fifth subunit of the (α4β2)2 β2 nicotinic ACh receptor modulates maximal ACh responses.

Pub. Date : 2018 Jun

PMID : 28600847






4 Functional Relationships(s)
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1 The fifth subunit of the (alpha4beta2)2 beta2 nicotinic ACh receptor modulates maximal ACh responses. Acetylcholine potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens
2 Here, we have examined the role of the fifth subunit in the ACh responses of the (alpha4beta2)2 beta2 nAChR type. Acetylcholine potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens
3 However, impairment of agonist binding to alpha4(+)/beta2(-) agonist sites by mutagenesis modified the effect of ACh on the rate of the reaction to MTS. Acetylcholine potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens
4 CONCLUSIONS AND IMPLICATIONS: The fifth subunit in the (alpha4beta2)2 beta2 receptor isoform modulates maximal ACh responses. Acetylcholine potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens