Title : Activated Platelets Induce an Anti-Inflammatory Response of Monocytes/Macrophages through Cross-Regulation of PGE2 and Cytokines.

Pub. Date : 2017

PMID : 28592915






2 Functional Relationships(s)
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1 Analyzing cocultures of platelets and murine bone marrow-derived macrophages or human monocytes, we found that collagen-activated platelets release high amounts of prostaglandin E2 (PGE2) that leads to an increased interleukin- (IL-) 10 release and a decreased tumor necrosis factor (TNF) alpha secretion out of the monocytes or macrophages. Dinoprostone tumor necrosis factor Homo sapiens
2 Analyzing cocultures of platelets and murine bone marrow-derived macrophages or human monocytes, we found that collagen-activated platelets release high amounts of prostaglandin E2 (PGE2) that leads to an increased interleukin- (IL-) 10 release and a decreased tumor necrosis factor (TNF) alpha secretion out of the monocytes or macrophages. Dinoprostone tumor necrosis factor Homo sapiens