Pub. Date : 2018 Mar
PMID : 28589946
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Using a murine bone marrow transplant (BMT) model, we show that overexpression of prostaglandin E2 (PGE2) post-BMT signals via EP2 or EP4 to induce cyclic adenosine monophosphate (cAMP), which activates protein kinase A or the exchange protein activated by cAMP (Epac) to induce cAMP response element binding-dependent transcription of IL-1beta leading to exacerbated lung injury in BMT mice. | Dinoprostone | interleukin 1 beta | Mus musculus |
2 | Using a murine bone marrow transplant (BMT) model, we show that overexpression of prostaglandin E2 (PGE2) post-BMT signals via EP2 or EP4 to induce cyclic adenosine monophosphate (cAMP), which activates protein kinase A or the exchange protein activated by cAMP (Epac) to induce cAMP response element binding-dependent transcription of IL-1beta leading to exacerbated lung injury in BMT mice. | Dinoprostone | interleukin 1 beta | Mus musculus |
3 | Induction of IL-1beta by PGE2 is time and dose dependent. | Dinoprostone | interleukin 1 beta | Mus musculus |
4 | Reducing PGE2 levels with indomethacin improved bacterial clearance and reduced IL-1beta-mediated acute lung injury in P. aeruginosa-infected BMT mice. | Dinoprostone | interleukin 1 beta | Mus musculus |