Pub. Date : 2017
PMID : 28588503
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hepcidin Protects Neuron from Hemin-Mediated Injury by Reducing Iron. | Iron | hepcidin antimicrobial peptide | Rattus norvegicus |
| 2 | In a recent study, we demonstrated the iron regulatory hormone hepcidin reduces brain iron in iron-overloaded rats. | Iron | hepcidin antimicrobial peptide | Rattus norvegicus |
| 3 | In a recent study, we demonstrated the iron regulatory hormone hepcidin reduces brain iron in iron-overloaded rats. | Iron | hepcidin antimicrobial peptide | Rattus norvegicus |
| 4 | In a recent study, we demonstrated the iron regulatory hormone hepcidin reduces brain iron in iron-overloaded rats. | Iron | hepcidin antimicrobial peptide | Rattus norvegicus |
| 5 | Therefore, we hypothesized that hepcidin might be able to reduce iron and then protect neurons from hemin or iron-mediated neurotoxicity in hemin-treated neuronal cells. | Iron | hepcidin antimicrobial peptide | Rattus norvegicus |
| 6 | Therefore, we hypothesized that hepcidin might be able to reduce iron and then protect neurons from hemin or iron-mediated neurotoxicity in hemin-treated neuronal cells. | Iron | hepcidin antimicrobial peptide | Rattus norvegicus |
| 7 | Here, we tested the hypothesis and demonstrated that ad-hepcidin and hepcidin peptide both have the ability to suppress the hemin-induced increase in LDH release and apoptotic cell numbers, to reduce cell iron and ferritin contents, and to inhibit expression of transferrin receptor 1, divalent metal transporter 1, and ferroportin 1 in hemin-treated neurons. | Iron | hepcidin antimicrobial peptide | Rattus norvegicus |
| 8 | Here, we tested the hypothesis and demonstrated that ad-hepcidin and hepcidin peptide both have the ability to suppress the hemin-induced increase in LDH release and apoptotic cell numbers, to reduce cell iron and ferritin contents, and to inhibit expression of transferrin receptor 1, divalent metal transporter 1, and ferroportin 1 in hemin-treated neurons. | Iron | hepcidin antimicrobial peptide | Rattus norvegicus |
| 9 | We conclude that hepcidin protects neuron from hemin-mediated injury by reducing iron via inhibition of expression of iron transport proteins. | Iron | hepcidin antimicrobial peptide | Rattus norvegicus |
| 10 | We conclude that hepcidin protects neuron from hemin-mediated injury by reducing iron via inhibition of expression of iron transport proteins. | Iron | hepcidin antimicrobial peptide | Rattus norvegicus |