Pub. Date : 2017 Jun 2
PMID : 28578659
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rapamycin (mTORC1 inhibitor) reduces the production of lactate and 2-hydroxyglutarate oncometabolites in IDH1 mutant fibrosarcoma cells. | Lactic Acid | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 2 | BACKGROUND: Multiple studies concluded that oncometabolites (e.g. D-2-hydroxyglutarate (2-HG) related to mutant isocitrate dehydrogenase 1/2 (IDH1/2) and lactate) have tumour promoting potential. | Lactic Acid | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |