Title : Identification of an optimized 2'-O-methylated trinucleotide RNA motif inhibiting Toll-like receptors 7 and 8.

Pub. Date : 2017 Sep

PMID : 28576825






1 Functional Relationships(s)
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1 On the basis of a naturally occurring 2"-O-methylated RNA sequence, we performed a systematic permutation of the methylated nucleotide as well as adjacent bases and hereby identify two minimal trinucleotide motifs within a 9-mer oligoribonucleotide that are necessary and sufficient to antagonize TLR7 and TLR8 activation, respectively. hippuric acid toll like receptor 7 Homo sapiens