Title : HCV T Cell Receptor Chain Modifications to Enhance Expression, Pairing, and Antigen Recognition in T Cells for Adoptive Transfer.

Pub. Date : 2017 Jun 16

PMID : 28573185






2 Functional Relationships(s)
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1 One approach to promote proper TCR chain pairing involves modifications of the introduced TCR genes: introducing a disulfide bridge, substituting murine for human constant regions, codon optimization, TCR chain leucine zipper fusions, and a single-chain TCR. Disulfides T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens
2 One approach to promote proper TCR chain pairing involves modifications of the introduced TCR genes: introducing a disulfide bridge, substituting murine for human constant regions, codon optimization, TCR chain leucine zipper fusions, and a single-chain TCR. Disulfides T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens