Title : Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation.

Pub. Date : 2017 May 30

PMID : 28564604






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 On a molecular level, diminished IDH1 activity results in reduced alpha-ketoglutarate (alphaKG) and NADPH production, paralleled by deficient carbon flux from glucose or acetate into lipids, exhaustion of reduced glutathione, increased levels of reactive oxygen species (ROS), and enhanced histone methylation and differentiation marker expression. Reactive Oxygen Species isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens
2 On a molecular level, diminished IDH1 activity results in reduced alpha-ketoglutarate (alphaKG) and NADPH production, paralleled by deficient carbon flux from glucose or acetate into lipids, exhaustion of reduced glutathione, increased levels of reactive oxygen species (ROS), and enhanced histone methylation and differentiation marker expression. Reactive Oxygen Species isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens