Pub. Date : 2017 Jul
PMID : 28556958
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The aim of this study was to examine the effect of NaAsO2 on AR signaling in LNCaP and 22Rv1 CRPC cells. | sodium arsenite | androgen receptor | Homo sapiens |
| 2 | RESULTS: NaAsO2 significantly reduced the translocation of AR and AR-Vs to the nucleus as well as their level in LNCaP and 22Rv1 cells. | sodium arsenite | androgen receptor | Homo sapiens |
| 3 | NaAsO2 promoted HSP90 acetylation by down-regulating HDAC6, which reduces the stability of AR in prostate cancer cells. | sodium arsenite | androgen receptor | Homo sapiens |
| 4 | CONCLUSIONS: Here, we show that NaAsO2 disrupts AR signaling at multiple levels by affecting AR expression, stability, and degradation in primary tumor cell cultures from prostate cancer patients as well as CRPC cell lines. | sodium arsenite | androgen receptor | Homo sapiens |
| 5 | CONCLUSIONS: Here, we show that NaAsO2 disrupts AR signaling at multiple levels by affecting AR expression, stability, and degradation in primary tumor cell cultures from prostate cancer patients as well as CRPC cell lines. | sodium arsenite | androgen receptor | Homo sapiens |