Pub. Date : 2017 Jul 13
PMID : 28552457
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The objective of the present study is to investigate the direct effects of butylated hydroxyanisole on rat brain neurosteroidogenic 5alpha-reductase 1 (SRD5A1), 3alpha-hydroxysteroid dehydrogenase (AKR1C14), and retinol dehydrogenase 2 (RDH2). | Butylated Hydroxyanisole | steroid 5 alpha-reductase 1 | Rattus norvegicus |
| 2 | Butylated hydroxyanisole inhibited SRD5A1, AKR1C14, and RDH2 with IC50 values of 4.731+-0.079muM, 5.753+-0.073muM, and over 100muM, respectively. | Butylated Hydroxyanisole | steroid 5 alpha-reductase 1 | Rattus norvegicus |
| 3 | Butylated hydroxyanisole is a competitive inhibitor for both SRD5A1 and AKR1C14. | Butylated Hydroxyanisole | steroid 5 alpha-reductase 1 | Rattus norvegicus |
| 4 | In conclusion, butylated hydroxyanisole is a potent inhibitor of SRD5A1 and AKR1C14, thus reducing the formation of active neurosteroids. | Butylated Hydroxyanisole | steroid 5 alpha-reductase 1 | Rattus norvegicus |