Title : Stimulation of cholesterol side-chain cleavage enzyme activity by cAMP and hCG in MA-10 Leydig tumor cells.

Pub. Date : 1988 Dec

PMID : 2855024






2 Functional Relationships(s)
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1 However, this stimulation of CSCC activity appears to be of limited significance when compared to the approximately 1000-fold or greater increase observed in progesterone production in the presence of hCG or dbcAMP. Progesterone hypertrichosis 2 (generalised, congenital) Homo sapiens
2 Our observations clearly indicate that given the proper hydroxy substrates (22R-hydroxycholesterol or 25-hydroxycholesterol), MA-10 Leydig cells are able to convert them into progesterone without any stimulation by steroidogenic stimuli, i.e. cAMP or hCG. Progesterone hypertrichosis 2 (generalised, congenital) Homo sapiens