Title : K-Ras mutation and amplification status is predictive of resistance and high basal pAKT is predictive of sensitivity to everolimus in biliary tract cancer cell lines.

Pub. Date : 2017 Sep

PMID : 28544747






1 Functional Relationships(s)
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1 Consistent with the known limitations of rapalogs, everolimus induced feedback-mediated activation of AKT in BTC cell lines, which could be overcome by cotreatment with an AKT inhibitor or ATP-competitive mTORC1/mTORC2 inhibitors. Everolimus CREB regulated transcription coactivator 1 Mus musculus