Title : HSP90 inhibitors potentiate PGF2α-induced IL-6 synthesis via p38 MAP kinase in osteoblasts.

Pub. Date : 2017

PMID : 28542188






2 Functional Relationships(s)
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1 We have previously reported that prostaglandin F2alpha (PGF2alpha), a potent bone remodeling mediator, stimulates the synthesis of interleukin-6 (IL-6) through p44/p42 mitogen-activated protein (MAP) kinase and p38 MAP kinase in osteoblast-like MC3T3-E1 cells, and that Rho-kinase acts at a point upstream of p38 MAP kinase. Dinoprost mitogen-activated protein kinase 3 Mus musculus
2 We have previously reported that prostaglandin F2alpha (PGF2alpha), a potent bone remodeling mediator, stimulates the synthesis of interleukin-6 (IL-6) through p44/p42 mitogen-activated protein (MAP) kinase and p38 MAP kinase in osteoblast-like MC3T3-E1 cells, and that Rho-kinase acts at a point upstream of p38 MAP kinase. Dinoprost mitogen-activated protein kinase 3 Mus musculus