Title : Apical and basolateral Na+/H+ exchange in the rabbit outer medullary thin descending limb of Henle: role in intracellular pH regulation.

Pub. Date : 1988 Dec

PMID : 2854165






6 Functional Relationships(s)
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1 In the presence of luminal amiloride (1 mM), the rate of decrease of pHi was significantly less, 0.73 +/- 0.18 pH/min. Amiloride glucose-6-phosphate isomerase Oryctolagus cuniculus
2 Steady-state pHi decreased 0.18 pH units following the addition of amiloride (1 mM) to the lumen (Na+ 140 mM lumen and bath). Amiloride glucose-6-phosphate isomerase Oryctolagus cuniculus
3 The rate of decrease of pHi was significantly less in the presence of 1 mM basolateral amiloride, 0.29 +/- 0.04 pH/min. Amiloride glucose-6-phosphate isomerase Oryctolagus cuniculus
4 Addition of 1 mM amiloride to the basolateral side (Na+ 140 mM lumen and bath) caused steady-state pHi to decrease significantly by 0.06 pH units. Amiloride glucose-6-phosphate isomerase Oryctolagus cuniculus
5 The rate of pHi recovery was inhibited 93% by 1 mM luminal amiloride. Amiloride glucose-6-phosphate isomerase Oryctolagus cuniculus
6 Addition of 1 mM basolateral amiloride inhibited the recovery of pHi by 97%. Amiloride glucose-6-phosphate isomerase Oryctolagus cuniculus