Pub. Date : 2017
PMID : 28539925
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | It was demonstrated that CXCL9(74-103) binds with high affinity to GAGs, competed with active chemokines for GAG binding and thereby inhibited CXCL8- and monosodium urate (MSU) crystal-induced neutrophil migration to joints. | Glycosaminoglycans | chemokine (C-X-C motif) ligand 9 | Mus musculus |
| 2 | This could be explained by (1) the lower affinity of CXCL9(74-93) for CS, the most abundant GAG in joints, and (2) by reduced competition with GAG binding of CXCL1, the most abundant ELR+ CXC chemokine in this gout model. | Glycosaminoglycans | chemokine (C-X-C motif) ligand 9 | Mus musculus |
| 3 | In summary, both CXCL9 peptides inhibited neutrophil migration in vivo through interference with GAG interactions in several animal models. | Glycosaminoglycans | chemokine (C-X-C motif) ligand 9 | Mus musculus |
| 4 | Shortening CXCL9(74-103) from the COOH-terminus limited its GAG-binding spectrum. | Glycosaminoglycans | chemokine (C-X-C motif) ligand 9 | Mus musculus |