Title : Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells.

Pub. Date : 2017 Jun 27

PMID : 28535155






1 Functional Relationships(s)
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1 RESULTS: Although APOBEC3B expression increased the incorporation of genomic uracil, invoked DDR biomarkers and caused cell cycle arrest, inactivation of p53 circumvented APOBEC3B-induced cell cycle arrest without reversing the increase in genomic uracil or DDR biomarkers. Uracil apolipoprotein B mRNA editing enzyme catalytic subunit 3B Homo sapiens