Pub. Date : 2017 Sep
PMID : 28533436
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin has shown anti-neoplastic efficiency partially through suppressing mTORC1. | Metformin | CREB regulated transcription coactivator 1 | Mus musculus |
| 2 | Mechanistic studies revealed that metformin sensitized ABT-263 via attenuating mTORC1-mediated cap-dependent translation of MCL-1 and survivin and weakening internal ribosome entry site (IRES)-dependent translation of XIAP Meanwhile, ABT-263 sensitized metformin through disrupting the BCL-XL/BIM complex. | Metformin | CREB regulated transcription coactivator 1 | Mus musculus |