Title : Targeting human telomerase RNA component using antisense oligonucleotide induces rapid cell death and increases ATO-induced apoptosis in APL cells.

Pub. Date : 2017 Aug 15

PMID : 28533173






1 Functional Relationships(s)
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1 The resulting data delineated that short-term treatment of the cells with hTR ASODN either as single agent or in combination with ATO resulted in apoptotic cell death through activation of DNA damage response via up-regulation of p73 and ATM coupled with down-regulation of c-Myc. ato MYC proto-oncogene, bHLH transcription factor Homo sapiens