Title : Mistranslation can enhance fitness through purging of deleterious mutations.

Pub. Date : 2017 May 19

PMID : 28524864






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Here we evolve the antibiotic resistance protein TEM-1 towards resistance on the antibiotic cefotaxime in an Escherichia coli strain with a high mistranslation rate. Cefotaxime hypothetical protein Escherichia coli
2 TEM-1 populations evolved in such strains endow host cells with a general growth advantage, not only on cefotaxime but also on several other antibiotics that ancestral TEM-1 had been unable to deactivate. Cefotaxime hypothetical protein Escherichia coli