Title : Protective Effects of Tormentic Acid, a Major Component of Suspension Cultures of Eriobotrya japonica Cells, on Acetaminophen-Induced Hepatotoxicity in Mice.

Pub. Date : 2017 May 18

PMID : 28524081






3 Functional Relationships(s)
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1 Furthermore, the Western blot analysis showed that TA blocked the protein expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), as well as the inhibition of nuclear factor-kappa B (NF-kappaB) and mitogen-activated protein kinases (MAPKs) activation in APAP-injured liver tissues. euscaphic acid nitric oxide synthase 2, inducible Mus musculus
2 Furthermore, the Western blot analysis showed that TA blocked the protein expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), as well as the inhibition of nuclear factor-kappa B (NF-kappaB) and mitogen-activated protein kinases (MAPKs) activation in APAP-injured liver tissues. euscaphic acid nitric oxide synthase 2, inducible Mus musculus
3 These results suggest that the hepatoprotective effects of TA may be related to its anti-inflammatory effect by decreasing thiobarbituric acid reactive substances (TBARS), iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6, and inhibiting NF-kappaB and MAPK activation. euscaphic acid nitric oxide synthase 2, inducible Mus musculus