Title : Antidiabetic Disruptors of the Glucokinase-Glucokinase Regulatory Protein Complex Reorganize a Coulombic Interface.

Pub. Date : 2017 Jun 20

PMID : 28516783






1 Functional Relationships(s)
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1 Metabolites such as fructose 6-phosphate and sorbitol 6-phosphate promote assembly of the GCK-GKRP complex, whereas fructose 1-phosphate and functionalized piperazines with potent in vivo antidiabetic activity disrupt the complex. fructose-6-phosphate glucokinase regulator Homo sapiens