Title : Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors.

Pub. Date : 2017 May 25

PMID : 28508636






1 Functional Relationships(s)
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1 The dCTP pyrophosphatase 1 (dCTPase) is a nucleotide pool "housekeeping" enzyme responsible for the catabolism of canonical and noncanonical nucleoside triphosphates (dNTPs) and has been associated with cancer progression and cancer cell stemness. nucleoside triphosphates inorganic pyrophosphatase 1 Homo sapiens