Title : Population Pharmacokinetic and Pharmacodynamic Modeling of Etelcalcetide in Patients with Chronic Kidney Disease and Secondary Hyperparathyroidism Receiving Hemodialysis.

Pub. Date : 2018 Jan

PMID : 28508378






2 Functional Relationships(s)
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1 This model included the role of PTH in Ca regulation, the feedback of Ca onto PTH production via the CaSR, and the activity of etelcalcetide plasma levels in increasing the sensitivity of the CaSR to Ca via the cooperative binding model. etelcalcetide hydrochloride calcium sensing receptor Homo sapiens
2 CONCLUSIONS: The current analysis confirms the putative mechanism of action of etelcalcetide as an allosteric activator of CaSR. etelcalcetide hydrochloride calcium sensing receptor Homo sapiens