Title : P53 suppresses ribonucleotide reductase via inhibiting mTORC1.

Pub. Date : 2017 Jun 20

PMID : 28507282






1 Functional Relationships(s)
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1 Pharmacological inhibition of mTORC1 with rapamycin, mTOR kinase with AZD8055 or protein kinase B with MK2206 resulted in decrease of RRM1 and RRM2 in Rh30 cells both in vitro and in mouse tumor xenografts. MK 2206 ribonucleotide reductase M2 Mus musculus