Pub. Date : 2017 May 30
PMID : 28507124
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase. | Thiophenes | DNA topoisomerase II alpha | Homo sapiens |
| 2 | We have identified a class of antibacterial thiophenes that target DNA gyrase with a unique mechanism of action and have activity against a range of bacterial pathogens, including strains resistant to fluoroquinolones. | Thiophenes | DNA topoisomerase II alpha | Homo sapiens |
| 3 | Mutations of conserved residues around this pocket affect activity of the thiophene inhibitors, consistent with allosteric inhibition of DNA gyrase. | Thiophenes | DNA topoisomerase II alpha | Homo sapiens |