Title : Dendritic cells enter lymph vessels by hyaluronan-mediated docking to the endothelial receptor LYVE-1.

Pub. Date : 2017 Jul

PMID : 28504698






3 Functional Relationships(s)
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1 Dendritic cells enter lymph vessels by hyaluronan-mediated docking to the endothelial receptor LYVE-1. Hyaluronic Acid lymphatic vessel endothelial hyaluronan receptor 1 Homo sapiens
2 In the current study we found that DCs docked to the basolateral surface of lymphatic vessels and transited to the lumen through hyaluronan-mediated interactions with the lymph-specific endothelial receptor LYVE-1, in dynamic transmigratory-cup-like structures. Hyaluronic Acid lymphatic vessel endothelial hyaluronan receptor 1 Homo sapiens
3 Our findings uncovered a previously unknown function for LYVE-1 and show that transit through the lymphatic network is initiated by the recognition of leukocyte-derived hyaluronan. Hyaluronic Acid lymphatic vessel endothelial hyaluronan receptor 1 Homo sapiens