Title : With me or against me: Tumor suppressor and drug resistance activities of SAMHD1.

Pub. Date : 2017 Aug

PMID : 28502830






1 Functional Relationships(s)
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1 However, SAMHD1 also can act as a resistance factor to nucleoside-based chemotherapies by hydrolyzing their active triphosphate metabolites, thereby reducing response of various malignancies to these anticancer drugs. Nucleosides SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 Homo sapiens