Title : Melatonin protects bone marrow mesenchymal stem cells against iron overload-induced aberrant differentiation and senescence.

Pub. Date : 2017 Oct

PMID : 28500782






2 Functional Relationships(s)
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1 Further study uncovered that melatonin inhibited the upregulation of p53, ERK and p38 protein expressions in BMSCs with iron overload. Iron tumor protein p53 Homo sapiens
2 Collectively, melatonin plays a protective role in iron overload-induced osteogenic differentiation dysfunction and senescence through blocking ROS accumulation and p53/ERK/p38 activation. Iron tumor protein p53 Homo sapiens