Pub. Date : 2017 May 11
PMID : 28492543
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BASP1 interacts with oestrogen receptor alpha and modifies the tamoxifen response. | Tamoxifen | brain abundant membrane attached signal protein 1 | Homo sapiens |
| 2 | Here we report that the transcriptional corepressor BASP1 interacts with ERalpha and in breast cancer cells, this interaction is enhanced by tamoxifen. | Tamoxifen | brain abundant membrane attached signal protein 1 | Homo sapiens |
| 3 | We find that BASP1 acts as a major selectivity factor in the transcriptional response of breast cancer cells to tamoxifen. | Tamoxifen | brain abundant membrane attached signal protein 1 | Homo sapiens |
| 4 | In all, 40% of the genes that are regulated by tamoxifen in breast cancer cells are BASP1 dependent, including several genes that are associated with tamoxifen resistance. | Tamoxifen | brain abundant membrane attached signal protein 1 | Homo sapiens |
| 5 | In all, 40% of the genes that are regulated by tamoxifen in breast cancer cells are BASP1 dependent, including several genes that are associated with tamoxifen resistance. | Tamoxifen | brain abundant membrane attached signal protein 1 | Homo sapiens |
| 6 | BASP1 elicits tumour-suppressor activity in breast cancer cells and enhances the antitumourigenic effects of tamoxifen treatment. | Tamoxifen | brain abundant membrane attached signal protein 1 | Homo sapiens |
| 7 | Our data have identified BASP1 as an ERalpha cofactor that has a central role in the transcriptional and antitumourigenic effects of tamoxifen. | Tamoxifen | brain abundant membrane attached signal protein 1 | Homo sapiens |