Title : Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury.

Pub. Date : 2017 Jul

PMID : 28490444






1 Functional Relationships(s)
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1 To determine the role of ceramide metabolism to hexosylceramides in kidney injury, we treated mice with a potent and highly specific inhibitor of glucosylceramide synthase, the enzyme responsible for catalyzing the glycosylation of ceramides to form glucosylceramides. Glucosylceramides UDP-glucose ceramide glucosyltransferase Mus musculus