Pub. Date : 2017 Jun 13
PMID : 28489606
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pantoprazole blocks the JAK2/STAT3 pathway to alleviate skeletal muscle wasting in cancer cachexia by inhibiting inflammatory response. | Pantoprazole | signal transducer and activator of transcription 3 | Mus musculus |
| 2 | Our results indicated that pantoprazole treatment can decrease the levels of serum IL-6 and TNF-alpha (56.3% and 67.6%, respectively), and inhibit the activation of the JAK2/STAT3 signaling pathway. | Pantoprazole | signal transducer and activator of transcription 3 | Mus musculus |
| 3 | CONCLUSION: Our findings suggested that pantoprazole can alleviate cancer cachexia skeletal muscle wasting by inhibiting the inflammatory response and blocking the JAK2/STAT3 or ubiquitin proteasome pathway. | Pantoprazole | signal transducer and activator of transcription 3 | Mus musculus |