Title : N-Glycosylation affects the stability and barrier function of the MUC16 mucin.

Pub. Date : 2017 Jun 30

PMID : 28487369






1 Functional Relationships(s)
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1 In N-glycosylation inhibition experiments, we find that treatment with tunicamycin and siRNA-mediated knockdown of the Golgi N-acetylglucosaminyltransferase I gene (MGAT1) induce partial loss of both total and cell-surface levels of the largest mucin, MUC16, and a concomitant reduction in glycocalyx barrier function. Tunicamycin LOC100508689 Homo sapiens