Title : Adrenocorticotropic hormone does not induce desensitization in human adrenal cells during fetal life.

Pub. Date : 1988 Oct

PMID : 2848596






2 Functional Relationships(s)
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1 When human fetal adrenal cells were incubated in the continuous presence of 10(-8) M ACTH for 72 h, DHAS production was increased compared to that of the untreated cultures (5-fold at 24 h and 50-fold at 72 h), and the cells remained responsive during the entire experimental period. Dehydroepiandrosterone Sulfate proopiomelanocortin Homo sapiens
2 One of the steroidogenic enzymatic steps stimulated by ACTH pretreatment was that of 17 alpha-hydroxylase/17, 20-lyase, since conversion of pregnenolone and 17 alpha-hydroxypregnenolone to DHAS was increased in a dose-dependent manner. Dehydroepiandrosterone Sulfate proopiomelanocortin Homo sapiens