Pub. Date : 2017 Jun 22
PMID : 28479296
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Intramitochondrial malonyl-CoA is generated by a malonyl-CoA synthetase, ACSF3, which produces malonyl-CoA from malonate, an endogenous competitive inhibitor of succinate dehydrogenase. | Malonyl Coenzyme A | acyl-CoA synthetase family member 3 | Homo sapiens |
| 2 | Intramitochondrial malonyl-CoA is generated by a malonyl-CoA synthetase, ACSF3, which produces malonyl-CoA from malonate, an endogenous competitive inhibitor of succinate dehydrogenase. | Malonyl Coenzyme A | acyl-CoA synthetase family member 3 | Homo sapiens |
| 3 | While ACSF3 was required for the metabolism and therefore detoxification of malonate, ACSF3-derived malonyl-CoA was specifically required for lysine malonylation of mitochondrial proteins. | Malonyl Coenzyme A | acyl-CoA synthetase family member 3 | Homo sapiens |
| 4 | Together, these data describe an essential role for ACSF3 in dictating the metabolic fate of mitochondrial malonate and malonyl-CoA in mammalian metabolism. | Malonyl Coenzyme A | acyl-CoA synthetase family member 3 | Homo sapiens |