Title : Celecoxib Alleviates Memory Deficits by Downregulation of COX-2 Expression and Upregulation of the BDNF-TrkB Signaling Pathway in a Diabetic Rat Model.

Pub. Date : 2017 Jun

PMID : 28466254






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Celecoxib Alleviates Memory Deficits by Downregulation of COX-2 Expression and Upregulation of the BDNF-TrkB Signaling Pathway in a Diabetic Rat Model. Celecoxib neurotrophic receptor tyrosine kinase 2 Rattus norvegicus
2 We found that brain-derived neurotrophic factor (BDNF) and phosphorylated tropomyosin-related kinase (p-TrkB) were decreased in diabetic rats but were effectively reversed by celecoxib treatment. Celecoxib neurotrophic receptor tyrosine kinase 2 Rattus norvegicus
3 The present findings provide novel data that celecoxib reverses memory deficits via probable downregulation of hippocampal COX-2 expression and upregulation of the BDNF-TrkB signaling pathway in a diabetic rat. Celecoxib neurotrophic receptor tyrosine kinase 2 Rattus norvegicus