Title : Picroside II Inhibits RANKL-Mediated Osteoclastogenesis by Attenuating the NF-κB and MAPKs Signaling Pathway In Vitro and Prevents Bone Loss in Lipopolysaccharide Treatment Mice.

Pub. Date : 2017 Dec

PMID : 28464271






1 Functional Relationships(s)
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1 Moreover, picroside II markedly decreased the phosphorylation of p38, ERK, JNK, p65, and I-kappaB degradation, and significantly suppressed c-Fos and nuclear factor of activated T-cells cytoplasmic 1 (NFATc1), both the key transcription factors during osteoclastogenesis. picroside II mitogen-activated protein kinase 1 Mus musculus