Pub. Date : 1988 Nov 15
PMID : 2846151
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Studies with DNA topoisomerase I purified from the wild-type and the mutant cells showed that the enzyme from the CptR cells was markedly resistant to camptothecin as assayed by the drug"s effects either on relaxation of supercoiled DNA or on stabilization of the covalent enzyme-DNA intermediate. | Camptothecin | DNA topoisomerase 1 | Cricetulus griseus |
| 2 | The presence of a camptothecin-resistant form of DNA topoisomerase I in the mutant cells provides further evidence that this enzyme is the cellular target of camptothecin. | Camptothecin | DNA topoisomerase 1 | Cricetulus griseus |
| 3 | The presence of a camptothecin-resistant form of DNA topoisomerase I in the mutant cells provides further evidence that this enzyme is the cellular target of camptothecin. | Camptothecin | DNA topoisomerase 1 | Cricetulus griseus |