Pub. Date : 2017 Aug 1
PMID : 28454878
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Salinomycin acts through reducing AKT-dependent thymidylate synthase expression to enhance erlotinib-induced cytotoxicity in human lung cancer cells. | salinomycin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | A combination of erlotinib and salinomycin resulted in synergistic enhancement of cytotoxicity and cell growth inhibition in NSCLC cells, accompanied with reduced protein levels of phospho-AKT(Ser473), phospho-AKT(Thr308), and TS. | salinomycin | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | A combination of erlotinib and salinomycin resulted in synergistic enhancement of cytotoxicity and cell growth inhibition in NSCLC cells, accompanied with reduced protein levels of phospho-AKT(Ser473), phospho-AKT(Thr308), and TS. | salinomycin | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Overexpression of a constitutive active AKT (AKT-CA) or Flag-TS expression vector reversed the salinomycin and erlotinib-induced synergistic cytotoxicity. | salinomycin | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | Overexpression of a constitutive active AKT (AKT-CA) or Flag-TS expression vector reversed the salinomycin and erlotinib-induced synergistic cytotoxicity. | salinomycin | AKT serine/threonine kinase 1 | Homo sapiens |
| 6 | Our findings suggested that the down-regulation of AKT-mediated TS expression by salinomycin enhanced the erlotinib-induced cytotoxicity in NSCLC cells. | salinomycin | AKT serine/threonine kinase 1 | Homo sapiens |