Title : Autophagy upregulates (pro)renin receptor expression via reduction of P62/SQSTM1 and activation of ERK1/2 signaling pathway in podocytes.

Pub. Date : 2017 Jul 1

PMID : 28450279






2 Functional Relationships(s)
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1 Cultured mouse podocytes were treated with the autophagy activators, rapamycin or Earle"s balanced salt solution (EBSS), for 48 h. Both rapamycin and EBSS significantly decreased p62 protein levels, increased ERK1/2 activation by phosphorylating pTpY185/187, and increased mRNA and protein expressions of PRR. Sirolimus mitogen-activated protein kinase 3 Mus musculus
2 ERK1/2 inhibitor U0126 significantly attenuated mRNA and protein expressions of PRR in podocytes treated with rapamycin. Sirolimus mitogen-activated protein kinase 3 Mus musculus