Title : Vasopressin and Vasopressin Antagonists in Heart Failure.

Pub. Date : 2017

PMID : 28432473






1 Functional Relationships(s)
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1 Of current pharmacological interest are the selective and non-selective vasopressin receptor antagonists (VRAs), which inhibit vasoconstriction and cardiac remodeling mediated by the V1a receptors in smooth blood vessels, and water retention (increased urine osmolality and decreased water excretion) by increasing aquaporin-2 water channels mediated by the V2 receptors in the renal collecting tubules. Water arginine vasopressin Homo sapiens