Title : Clozapine reduces Toll-like receptor 4/NF-κB-mediated inflammatory responses through inhibition of calcium/calmodulin-dependent Akt activation in microglia.

Pub. Date : 2018 Feb 2

PMID : 28431901






3 Functional Relationships(s)
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1 Clozapine reduces Toll-like receptor 4/NF-kappaB-mediated inflammatory responses through inhibition of calcium/calmodulin-dependent Akt activation in microglia. Clozapine AKT serine/threonine kinase 1 Homo sapiens
2 Clozapine downregulated LPS-induced Akt phosphorylation at Ser-473. Clozapine AKT serine/threonine kinase 1 Homo sapiens
3 These results suggest that clozapine exhibits anti-inflammatory activity through the inhibition of Ca2+/CaM/Akt-mediated NF-kappaB activation. Clozapine AKT serine/threonine kinase 1 Homo sapiens