Pub. Date : 2017 Jul 7
PMID : 28431340
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lorlatinib has demonstrated decent kinase selectivity, promising pharmacokinetic profile, selective brain-penetration and strong antiproliferative activity in several ALK/ROS1-driven tumor models. | lorlatinib | ROS proto-oncogene 1, receptor tyrosine kinase | Homo sapiens |
| 2 | The current review describes the activity spectrum, key events from discovery to clinical applications and the evidences that lorlatinib acts as an ALK/ROS1 inhibitor in clinical settings. | lorlatinib | ROS proto-oncogene 1, receptor tyrosine kinase | Homo sapiens |