Title : Engineered jadomycin analogues with altered sugar moieties revealing JadS as a substrate flexible O-glycosyltransferase.

Pub. Date : 2017 Jul

PMID : 28429060






1 Functional Relationships(s)
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1 Here, we report the use of a combinatorial biosynthetic approach to probe the substrate flexibility of JadS, the GT in jadomycin biosynthesis, towards different non-native NDP-sugar substrates, enabling us to identify six jadomycin B analogues with different sugar moieties. Sugars norrin cystine knot growth factor NDP Homo sapiens